SCIENCES

Reactive Gliosis and Glial scar & NGDF & INSF

REACTIVE GLIOSIS AND GLIAL SCAR
Gliosis refers to an important cellular process by which glial cells respond to Central Nervous System (CNS) damage.
When severe damage to the CNS occurs, reactive gliosis generates a scar known as a glial scar around
the injury site, which consists of other cells such as astrocytes and microglia, and protein structures such as
chondroitin sulfate proteoglycan (CSPG).

The glial scar isolates the damaged region and protects healthy tissue.
However, the glial scar also prevents axonal regrowth in the damaged area and in certain situations accelerates neurodegeneration.

REACTIVE GLIOSIS AND GLIAL SCAR image

NGDF
NGDF, a novel neuropeptide secreted by astrocytes, has been discovered to play a major role in gliosis and the glial scarring process.
NGDF levels in the blood have been found to be significantly elevated in patients with brain injuries or neurodegenerative diseases.
Treatment with an NGDF-neutralizing antibody effectively prevented detrimental glial scar formation
in animal models of brain injury and chronic neurodegenerative diseases.

The neurological changes caused by the NGDF antibody ultimately led to the improvement of cognitive and behavioral function in animal models.
INSF
INSF, a novel neuropeptide secreted by neurons, has been discovered to modulate interneuron function such as reflexes,
neuronal oscillations, and neurogenesis in the brain.
Treatment with an INSF-neutralizing antibody effectively alleviated neuropathic pain in animal models.
Additionally, the INSF antibody will be assessed for its therapeutic potential
in various animal models of motor neuron related and psychiatric disorders.