Gliosis refers to an important cellular process by which glial cells respond to Central Nervous System (CNS) damage.
When severe damage to the CNS occurs, reactive gliosis generates a scar known as a glial scar around
the injury site, which consists of other cells such as astrocytes and microglia, and protein structures such as
chondroitin sulfate proteoglycan (CSPG).
The glial scar isolates the damaged region and protects healthy tissue.
However, the glial scar also prevents axonal regrowth in the damaged area and in certain situations accelerates neurodegeneration.