Peer-Reviewed Papers

• Kwak, H., Cho, E. H., Cho, E. B., Lee, Y. N., Shahapal, A., Yong, H. J., Reyes-Alcaraz, A., Jeong, Y., Lee, Y., Lee, M., Ha, N., Oh, S., Lee, J. K., Lee, W. S., Kim, W. K., Yoo, S., Kwon, S. G., Hwang, J. I., & Seong, J. Y. (2024). Is FAM19A5 an adipokine? Peripheral FAM19A5 in wild-type, FAM19A5 knockout, and LacZ knockin mice. Molecules and cells, 100125. Advance online publication.

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• Kim, W. K., Seong, J. Y., & Lee, G. M. (2024). Development, physico-chemical characterization, and in vivo stability of a novel aglycosylated monoclonal antibody targeting FAM19A5. Biotechnology and Bioprocess Engineering, 1–14.

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• Park, S., Shahapal, A., Yoo, S., Kwak, H., Lee, M., Lee, S. M., Hwang, J. I., & Seong, J. Y. (2024). FAM19A5 Deficiency Mitigates the Aβ Plaque Burden and Improves Cognition in Mouse Models of Alzheimer's Disease. Experimental neurobiology, 33(4), 193–201

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• Jeong, I., Yun, S., Shahapal, A., Cho, E. B., Hwang, S. W., Seong, J. Y., & Park, H. C. (2021). FAM19A5l Affects Mustard Oil-Induced Peripheral Nociception in Zebrafish. Molecular neurobiology, 58(9), 4770–4785.

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• Lee, H. L., Seok, H. Y., Ryu, H. W., Cho, E. B., Kim, B. C., Kim, B. J., Min, J. H., Seok, J. M., Shin, H. Y., Kang, S. Y., Kwon, O. H., Lee, S. S., Oh, J., Sohn, E. H., Huh, S. Y., Cho, J. Y., Seong, J. Y., & Kim, B. J. (2020). Serum FAM19A5 in neuromyelitis optica spectrum disorders: Can it be a new biomarker representing clinical status? Multiple sclerosis (Houndmills, Basingstoke, England), 26(13), 1700–1707.

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• Han, K. M., Tae, W. S., Kim, A., Kang, Y., Kang, W., Kang, J., Kim, Y. K., Kim, B., Seong, J. Y., & Ham, B. J. (2020). Serum FAM19A5 levels: A novel biomarker for neuroinflammation and neurodegeneration in major depressive disorder. Brain, behavior, and immunity, 87, 852–859.

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• Kang, D., Kim, H. R., Kim, K. K., Kim, D. H., Jeong, B., Jin, S., Park, J. W., Seong, J. Y., & Lee, B. J. (2020). Brain-specific chemokine FAM19A5 induces hypothalamic inflammation. Biochemical and biophysical research communications, 523(4), 829–834.

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• Yong, H. J., Ha, N., Cho, E. B., Yun, S., Kim, H., Hwang, J. I., & Seong, J. Y. (2020). The unique expression profile of FAM19A1 in the mouse brain and its association with hyperactivity, long-term memory and fear acquisition. Scientific reports, 10(1), 3969.

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• Shahapal, A., Cho, E. B., Yong, H. J., Jeong, I., Kwak, H., Lee, J. K., Kim, W., Kim, B., Park, H. C., Lee, W. S., Kim, H., Hwang, J. I., & Seong, J. Y. (2019). FAM19A5 Expression During Embryogenesis and in the Adult Traumatic Brain of FAM19A5-LacZ Knock-in Mice. Frontiers in neuroscience, 13, 917.

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Pre-Print Manuscript

• Kim, H.-B., Yoo, S., Kwak, H., Ma, S.-X., Kim, R., Lee, M., Ha, N., Pyo, S., Kwon, S.-G., Cho, E.-H., Lee, S.-M., Jang, J., Kim, W., Park, H.-C., Baek, M., Park, Y., Park, J.-Y., Park, J.-W., Hwang, S. W., Hwang, J. I., & Seong, J. Y. (2024). Inhibition of FAM19A5 restores synaptic loss and improves cognitive function in mouse models of Alzheimer’s disease. BioRxiv, 2023.11.22.568357.

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Peer-Reviewed Papers

• Cha, J. J., Park, B. Y., Yoon, S. G., Park, H. J., Yoo, J. A., Ghee, J. Y., Cha, D. R., Seong, J. Y., & Kang, Y. S. (2023). Spexin-based galanin receptor 2 agonist improves renal injury in mice with type 2 diabetes. Animal cells and systems, 27(1), 187–196.

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• Lee, Y. N., Reyes-Alcaraz, A., Yun, S., Lee, C. S., Hwang, J. I., & Seong, J. Y. (2020). Exploring the molecular structures that confer ligand selectivity for galanin type II and III receptors. PloS one, 15(3), e0230872.

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• Yun S, Reyes-Alcaraz A, Lee YN, Yong HJ, Choi J, Ham BJ, Sohn JW, Kim DH, Son GH, Kim H, Kwon SG, Kim DS, Kim BC, Hwang JI, Seong JY (2019) Spexin-based galanin receptor type 2 agonist for comorbid mood disorders and abnormal body weight. Front Neurosci 13:391.

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• Jeong, I., Kim, E., Seong, J. Y., & Park, H. C. (2019). Overexpression of Spexin 1 in the Dorsal Habenula Reduces Anxiety in Zebrafish. Frontiers in neural circuits, 13, 53.

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• Yun S, Reyes-Alcaraz A, Lee YN, Yong HJ, Choi J, Ham BJ, Sohn JW, Kim DH, Son GH, Kim H, Kwon SG, Kim DS, Kim BC, Hwang JI, Seong JY (2019) Spexin-based galanin receptor type 2 agonist for comorbid mood disorders and abnormal body weight. Front Neurosci 13:391.

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• Kim, E., Jeong, I., Chung, A. Y., Kim, S., Kwon, S. H., Seong, J. Y., & Park, H. C. (2019). Distribution and neuronal circuit of spexin 1/2 neurons in the zebrafish CNS. Scientific reports, 9(1), 5025.

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• Reyes-Alcaraz, A., Lee, Y. N., Yun, S., Hwang, J. I., & Seong, J. Y. (2018). Conformational signatures in β-arrestin2 reveal natural biased agonism at a G-protein-coupled receptor. Communications biology, 1, 128.

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• Reyes-Alcaraz, A., Lee, Y. N., Son, G. H., Kim, N. H., Kim, D. K., Yun, S., Kim, D. H., Hwang, J. I., & Seong, J. Y. (2016). Development of Spexin-based Human Galanin Receptor Type II-Specific Agonists with Increased Stability in Serum and Anxiolytic Effect in Mice. Scientific reports, 6, 21453.

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• Yun, S., Kim, D. K., Furlong, M., Hwang, J. I., Vaudry, H., & Seong, J. Y. (2014). Does Kisspeptin Belong to the Proposed RF-Amide Peptide Family?. Frontiers in endocrinology, 5, 134.

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• Kim, D. K., Yun, S., Son, G. H., Hwang, J. I., Park, C. R., Kim, J. I., Kim, K., Vaudry, H., & Seong, J. Y. (2014). Coevolution of the spexin/galanin/kisspeptin family: Spexin activates galanin receptor type II and III. Endocrinology, 155(5), 1864–1873.

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